منابع مشابه
Genetic and Epigenetic landscape of Germline Stem Cells
Elucidating the critical epigenetics events involved in differentiation and reprogramming of cells to primordial germ cells (PGCs) is among the interesting issues in stem cell research. Here, I will talk about critical transcription factors and global hypomethylation in development of germ cells. Evidence strongly suggests that the earliest PGCs emerging in the E7.25 mouse embryo epiblast have...
متن کاملGermline stem cells.
Stem cells support tissue maintenance by balancing self-renewal and differentiation. Germline stem cells (GSCs) belong to a kind of stem cells that are crucial to development and tissue homeostasis with their ability to both differentiate into gametes and maintain an undifferentiated state by their self-renewal property. The GSCs are unique in that they transmit genetic information from parent ...
متن کاملgenetic and epigenetic landscape of germline stem cells
elucidating the critical epigenetics events involved in differentiation and reprogramming of cells to primordial germ cells (pgcs) is among the interesting issues in stem cell research. here, i will talk about critical transcription factors and global hypomethylation in development of germ cells. evidence strongly suggests that the earliest pgcs emerging in the e7.25 mouse embryo epiblast have ...
متن کاملHuman embryonic stem cells assemble and fulfill their developmental destiny.
How do we study the endocrine cell differentiation of the placenta? The accepted course of action dictates that you use primary trophoblast cell cultures derived from human placentas. This is accomplished using methods to isolate cytotrophoblasts that possess the potential to spontaneously differentiate into endocrinologically active syncytial trophoblast within a prescribed period of time (1)....
متن کاملPluripotency of male germline stem cells.
The ethical issues and public concerns regarding the use of embryonic stem (ES) cells in human therapy have motivated considerable research into the generation of pluripotent stem cell lines from non-embryonic sources. Numerous reports have shown that pluripotent cells can be generated and derived from germline stem cells (GSCs) in mouse and human testes during in vitro cultivation. The gene ex...
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ژورنال
عنوان ژورنال: Cell Stem Cell
سال: 2012
ISSN: 1934-5909
DOI: 10.1016/j.stem.2012.05.016